Electrophysiological experiments often require determining the neuroanatomical location of a recording probe when it was inserted in the brain. Using probe trajectory reconstruction, one can use histological slices to estimate where in the brain neural signals were recorded. The classic approach is to align a histological brain slice to a stereotactic atlas and manually designate the recording area, but more modern approaches also use the neurophysiological signals themselves to improve the reconstruction quality.
Some example programs you might use are:
- SHARP-track
- Universal Probe Finder
External references
- SHARP-track: https://www.biorxiv.org/content/10.1101/447995v1
- Universal Probe Finder: https://www.biorxiv.org/content/10.1101/2022.06.20.496782v1